CNS Indications
The CNS drug pipeline organized by condition — 51 psychiatric and neurological indications, MeSH/ICD-11 coded, each with the compounds in development and trials recruiting.38 indications with tracked programs · 108 compounds across the pipeline · 93 upcoming readouts.
Neurocognitive Disorders (10)
- Alzheimer's disease7 compounds+6 in subtypes1,537 trials2 subtypes
- Agitation in Alzheimer's disease4 compounds2 Phase 3+10 trials
- Parkinson's disease3 compounds1 Phase 3+1,331 trials1 subtype
- Alzheimer's disease psychosis2 compounds1 Phase 3+4 trials
- Lewy body dementia psychosis1 compound2 trials
- Postoperative delirium1 compound1 trial
- Frontotemporal dementia63 trials
- Huntington's disease141 trials
- Lewy body dementia+1 in subtypes65 trials1 subtype
- Parkinson's disease psychosis19 trials
Neurological Disorders (6)
- Epilepsy3 compounds2 Phase 3+880 trials
- Migraine2 compounds823 trials
- Tourette syndrome2 compounds1 Phase 3+78 trials
- Amyotrophic lateral sclerosis1 compound1 Phase 3+429 trials
- Multiple sclerosis1,155 trials
- Neuropathic pain630 trials
Substance Use Disorders (6)
- Alcohol use disorder1 compound369 trials
- Cannabis use disorder1 compound109 trials
- Opioid use disorder1 compound368 trials
- Tobacco use disorder1 compound492 trials
- Cocaine use disorder97 trials
- Stimulant use disorder21 trials1 subtype
Anxiety & Trauma Disorders (5)
- Post-traumatic stress disorder6 compounds3 Phase 3+482 trials
- Generalized anxiety disorder5 compounds1 Phase 3+185 trials
- Social anxiety disorder5 compounds2 Phase 3+96 trials
- Obsessive-compulsive disorder1 compound176 trials
- Panic disorder69 trials
Mood Disorders (5)
- Major depressive disorder40 compounds9 Phase 3++11 in subtypes1,650 trials2 subtypes
- Treatment-resistant depression8 compounds1 Phase 3+156 trials
- Bipolar depression6 compounds2 Phase 3+339 trials
- Bipolar disorder4 compounds2 Phase 3++6 in subtypes778 trials1 subtype
- Postpartum depression3 compounds1 Phase 3+77 trials
Neurodevelopmental Disorders (5)
- Attention-deficit/hyperactivity disorder3 compounds2 Phase 3+652 trials
- Autism spectrum disorder2 compounds1 Phase 3+420 trials
- Down Syndrome1 compound2 trials
- Fragile X syndrome73 trials
- Rett syndrome46 trials
Sleep-Wake Disorders (4)
- Narcolepsy5 compounds3 Phase 3+12 trials
- Idiopathic Hypersomnia2 compounds1 Phase 3+2 trials
- Excessive daytime sleepiness1 compound1 Phase 3+57 trials
- Insomnia1 compound1 Phase 3+427 trials
Eating Disorders (2)
- Anorexia nervosa1 compound63 trials
- Binge eating disorder1 compound1 Phase 3+62 trials
Psychotic Disorders (2)
- Schizophrenia17 compounds9 Phase 3+1,706 trials
- Schizoaffective disorder326 trials
Cerebrovascular & Acute Brain Injury (1)
- Intracerebral hemorrhage1 compound4 trials
Movement Disorders (1)
- Tardive Dyskinesia1 compound1 trial
Neurodegenerative Disorders (1)
- Multiple System Atrophy1 compound1 trial
Pain (1)
- Fibromyalgia2 compounds2 Phase 3+4 trials
Suicide & Self-Harm (1)
- Suicidal ideation81 trials
Trauma and Stressor-Related Disorders (1)
- Acute Stress Disorder2 compounds2 trials