What are the next migraine trial readouts?

Upcoming catalysts include TNX-1900 (2023-12-06) and BHV-2100 (1H 2025).

How many clinical trials are recruiting for migraine?

83 drug-interventional migraine trials are currently recruiting participants, out of 823 registered interventional trials.

Neurological Disorders

Migraine drug pipeline

ICD-11 8A80
MeSH D008881

2 compounds from 2 companies are in active clinical development for migraine.

2Compounds

2Companies

0Phase 3+

2Upcoming readouts

88Trials recruiting

Phase 2 1
Discontinued 1

Mechanisms: Small molecule (1) · Peptide (1)

Pipeline data compiled July 2026 · every fact sourced.

Upcoming readouts & recent results

2023-12-06AnticipatedTNX-1900Topline data
1H 2025AnticipatedBHV-2100Topline dataNCT06603623
Topline proof-of-concept efficacy data for BHV-2100 in the acute treatment of migraine (Phase 2, NCT06603623) ↗

See the full catalyst calendar →

Compounds in development (2)

Compound	Company	Phase	Status	Mechanism
BHV-2100	Biohaven Ltd.	Phase 2	Active	TRPM3 Antagonist
TNX-1900	Tonix Pharmaceuticals Holding Corp.	Discontinued	Discontinued	Oxytocin receptor Agonist

Trials recruiting now (83)

83 drug-interventional migraine trials recruiting now, of 823 registered interventional trials. Browse all on ClinicalTrials.gov →

Phase 4Comparison of Propranolol, Flunarizine and Their Combination in Preventing Migraine in Adults in a Tertiary Care Hospital in Bangladesh
Propranolol 80 mg, Flunarizine 10 mg, Propranolol 40 mg + Flunarizine 10mg
Chittagong Medical Collegen=177Bangladesh · 1 siteStarted Jul 2026NCT07655700
Phase 4Comparing Migraine Preventive Therapies vs. Anti-CGRP Therapies for Tinnitus in Patients With Migraine (COMPACT-PM)
Galcanezumab, Erenumab 70 mg, Eptinezumab, Atogepant, Amitriptyline, Nortriptyline, propranolol, Verapamil SR 120 mg, Candesartan, topiramate
Stanford Universityn=120Started Jul 2026NCT07655440
Phase 4A Study to Learn About the Safety of Taking an Additional Dose of the Medicine Rimegepant in Adults With Migraine
Rimegepant
Pfizer Inc.n=400United States · 3 sitesStarted May 2026NCT07609914
Phase 4Rimegepant as Preemptive Treatment for Predictable Trigger-Induced Migraine in Adult Patients in the US
Rimegepant 75 MG
Medstar Health Research Instituten=60United States · 1 siteStarted Sep 2025NCT07301008
Phase 4Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study
Atogepant 60 mg, Propranolol 160 mg, Topiramate 100 mg
Mayo Clinicn=1,335United States · 35 sitesStarted Jul 2025NCT06972056
Phase 4Comparison of the Effectiveness of First-line Preventive Treatment of Migraine in Primary Care
Topiramate, Flunarizine, Amitriptyline, Propranolol
Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurinan=460Started Oct 2024NCT06499116
Phase 4A Comparison of Nurtec ODT to Maxalt MLT-ODT in Adult ED Patients With Migraine Headache
Rimegepant, Rizatriptan Benzoate
Antonios Likourezosn=80United States · 1 siteStarted Sep 2024NCT06473597
Phase 4Impact of Combined Oral Contraceptive Pills on Migraine
Combined oral contraceptive, Vaginal Ring
Kafrelsheikh Universityn=400Egypt · 1 siteStarted Jul 2024NCT06509503
Phase 4Role of Ultrasound Guide Greater Occipital Nerve Block at Second Cervical Vertebra in Migraine Headache Prophylaxis
Placebo, Bupivacaine
Mahidol Universityn=108Thailand · 1 siteStarted May 2024NCT06432127
Phase 4Effectiveness and Tolerability of Zavegepant for Acute Migraine Treatment Among Those Using CGRP Targeting Preventive Medications
Zavegepant
Mayo Clinicn=200United States · 1 siteStarted Mar 2024NCT06401642
Phase 4Migraine and High Flow Oxygenotherapy at the Emergency Department (MiOx)
oxygenotherapy, placebo air aerosol
Centre Hospitalier Universitaire de Nicen=70France · 1 siteStarted Oct 2023NCT04925414
Phase 4Assessment of Oral Caffeine Intake in Changing the Severity of Acute Migraine Attack Using VAS Score Among Patients Attending Headache and Neurology Outpatients Clinic of Ainshams University Hospitals
Caffeine (200 mg), triptans, NSAID (Nonsteroidal anti-inflammatory drugs), Paracetamol (acetaminophen)
Ain Shams Universityn=120Egypt · 1 siteStarted Apr 2023NCT07022496

Showing the 12 most advanced of 83 recruiting drug trials · see all on ClinicalTrials.gov →

Frequently asked

How many drugs are in development for migraine?: 2 compounds from 2 companies are in active clinical development for migraine.
What are the next migraine trial readouts?: Upcoming catalysts include TNX-1900 (2023-12-06) and BHV-2100 (1H 2025).
How many clinical trials are recruiting for migraine?: 83 drug-interventional migraine trials are currently recruiting participants, out of 823 registered interventional trials.