How many clinical trials are recruiting for fragile x syndrome?

10 drug-interventional fragile x syndrome trials are currently recruiting participants, out of 73 registered interventional trials.

Neurodevelopmental Disorders

Fragile X syndrome drug pipeline

ICD-11 LD55
MeSH D005600

Compounds in development

No compounds populated for this indication yet — see registered trials below.

Trials recruiting now (10)

10 drug-interventional fragile x syndrome trials recruiting now, of 73 registered interventional trials. Browse all on ClinicalTrials.gov →

Phase 4Metformin in Children With Fragile X Syndrome
Metformin, Placebo
Children's Hospital of Fudan Universityn=20China · 1 siteStarted Dec 2021NCT05120505
Phase 4The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome
methylphenidate, fluoxetin, risperidone
The Chaim Sheba Medical Centern=400Israel · 1 siteStarted May 2001NCT00768820
Phase 2/3A Study to Investigate the Effects and Safety of SPG601 for the Treatment of Fragile X Syndrome in Male Participants
SPG601, Placebo
Spinogenixn=248Started Mar 2026NCT07439510
Phase 2Safety, Tolerability, and Preliminary Effectiveness of CTH120 in Fragile X Syndrome
CTH120
Connecta Therapeutics, S.L.n=30Spain · 2 sitesStarted May 2026NCT07654114
Phase 2Inhibition of Aggressive Behavior in Participants With Fragile X Syndrome
SRX246, Placebo
Azevan Pharmaceuticalsn=80United States · 3 sitesStarted Mar 2026NCT07328529
Phase 2Study of MRM-3379 in Male Participants With Fragile X Syndrome (BLOOM)
Low dose of MRM-3379, Middle Dose of MRM-3379, High dose of MRM-3379, Placebo, Low dose of MRM-3379 Open-Label
Mirum Pharmaceuticals, Inc.n=60United States · 15 sitesStarted Nov 2025NCT07209462
Phase 2Effect of CBD on the Brain
CBD Oral Solution (eCBD system Target), Placebo
Université de Sherbrooken=50Started May 2025NCT06261450
Phase 2Effect of CANnabidiol on Anxiety and GABAergic Function in Individuals with Fragile-X Syndrome
CBD Oral Solution, Placebo
Université de Sherbrooken=40Started May 2025NCT06261502
Phase 2Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders
Sertraline
Holland Bloorview Kids Rehabilitation Hospitaln=130Canada · 8 sitesStarted Sep 2024NCT06081348
Phase 1Sensitivity of the NIH Toolbox to Stimulant Treatment in Intellectual Disabilities
Methylphenidate Oral Solution
University of California, Davisn=68United States · 3 sitesStarted Feb 2023NCT05301361

Frequently asked

How many clinical trials are recruiting for fragile x syndrome?: 10 drug-interventional fragile x syndrome trials are currently recruiting participants, out of 73 registered interventional trials.