How many clinical trials are recruiting for obsessive-compulsive disorder?

19 drug-interventional obsessive-compulsive disorder trials are currently recruiting participants, out of 176 registered interventional trials.

Anxiety & Trauma Disorders

Obsessive-compulsive disorder drug pipeline

ICD-11 6B20
MeSH D009771

2 compounds from 2 companies are in active clinical development for obsessive-compulsive disorder.

2Compounds

2Companies

0Phase 3+

22Trials recruiting

Discontinued2

Mechanisms: Small molecule (2)

Pipeline data compiled September 2026 · every fact sourced.

Upcoming readouts & recent results

2025-08-11ReportedTroriluzole (BHV-4157)Topline datamissed
Phase 3 OCD trial completed with no efficacy signal; Biohaven discontinues troriluzole in OCD. ↗
2020-06-24ReportedTroriluzole (BHV-4157)Topline datamissedNCT03299166
Phase 2/3 OCD proof-of-concept missed its Week-12 Y-BOCS primary endpoint (p=0.22). ↗

See the full catalyst calendar →

Compounds in development (2)

Compound	Company	Phase	Status	Mechanism
Mavoglurant	Novartis Pharma AG	Discontinued	Discontinued	mGlu5 NAM
Troriluzole (BHV-4157)	Biohaven Ltd.	Discontinued	Discontinued	EAAT2 Modulator

Trials recruiting now (19)

19 drug-interventional obsessive-compulsive disorder trials recruiting now, of 176 registered interventional trials. Browse all on ClinicalTrials.gov →

Phase 2Semaglutide (Wegovy) Treatment for Trichotillomania
Semaglutide
University of Chicagon=10Started Jun 2026NCT07282769
Phase 2Valbenazine in Obsessive Compulsive Disorder
Valbenazine, Placebo
University of Chicagon=30Started Jun 2026NCT07111988
Phase 2Aripiprazole in Body Focused Repetitive Behaviors
Placebo, Aripiprazole
University of Chicagon=100United States · 1 siteStarted Jun 2026NCT05545891
Phase 2MDMA-Assisted CBT for OCD (MDMA-CBT4OCD Study)
3,4-Methyl enedioxy methamphetamine, Methamphetamine
Carolyn Rodriguezn=40United States · 1 siteStarted Sep 2025NCT05783817
Phase 2Safety and Efficacy of Pramipexole Treatment in Resistant Obsessive-Compulsive Disorder (OCD)
Pramipexole 0.088mg/tid, Pramipexole 0.18 mg/tid, Pramipexole 0.35 mg/tid
Clinical Academic Center (2CA-Braga)n=48Portugal · 1 siteStarted Aug 2024NCT06611592
Phase 2Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)
Ketamine, Naltrexone Pill
Stanford Universityn=150United States · 1 siteStarted Feb 2024NCT05940324
Phase 2Efficacy of Valbenazine for the Treatment of Trichotillomania in Adults
Valbenazine Oral Capsule
Yale Universityn=20United States · 1 siteStarted Feb 2024NCT05207085
Phase 2Rituximab Treatment for Psychosis And/or Obsessive Compulsive Disorder with Probable Immune System Involvement
Rituximab
Uppsala University Hospitaln=40Sweden · 1 siteStarted May 2022NCT04323566
Phase 2Study of Dextromethorphan in OCD and Related Disorders
Fluoxetine, Dextromethorphan
Stanford Universityn=60United States · 1 siteStarted Jan 2022NCT04899687
Phase 2Efficacy of Nitrous Oxide in OCD: Pilot Study
Nitrous Oxide, Nitrogen
Stanford Universityn=45United States · 1 siteStarted Apr 2021NCT03826693
Phase 2Pragmatic Trial of Obsessive-compulsive Disorder
Sertraline 200 milligram(mg), Sertraline 300 milligram(mg), Fluvoxamine, Venlafaxine, Augment with Memantine, Augment with Aripiprazole
Shanghai Mental Health Centern=1,600China · 1 siteStarted Sep 2020NCT04539951
Phase 1/2Psilocybin for Treatment of OCD-2
Low Dose Psilocybin, High Dose Psilocybin
Francisco A Morenon=20United States · 1 siteStarted Sep 2026NCT06992999

Showing the 12 most advanced of 19 recruiting drug trials · see all on ClinicalTrials.gov →

Frequently asked

How many drugs are in development for obsessive-compulsive disorder?: 2 compounds from 2 companies are in active clinical development for obsessive-compulsive disorder.
How many clinical trials are recruiting for obsessive-compulsive disorder?: 19 drug-interventional obsessive-compulsive disorder trials are currently recruiting participants, out of 176 registered interventional trials.