How many clinical trials are recruiting for cocaine use disorder?

10 drug-interventional cocaine use disorder trials are currently recruiting participants, out of 98 registered interventional trials.

Substance Use Disorders

Cocaine use disorder drug pipeline

ICD-11 6C45
MeSH D019970
Subtype of Stimulant use disorder

2 compounds from 2 companies are in active clinical development for cocaine use disorder.

2Compounds

2Companies

0Phase 3+

11Trials recruiting

Phase 22

Mechanisms: Small molecule (2)

Pipeline data compiled October 2026 · every fact sourced.

Upcoming readouts & recent results

2026-09-21ReportedEMB-001 (metyrapone/oxazepam)Registry resultsmissedNCT04501874
Phase 2 EMB-001 in cocaine use disorder misses primary endpoint: continuous abstinence weeks 11-13 in 2/41 (EMB-001) vs 0/41 (placebo), p=0.092. ↗
2025-04-02ReportedMavoglurantFull resultsmetNCT03242928
Phase 2 full results published in Science Translational Medicine: mavoglurant reduced cocaine use versus placebo in 68 adults with cocaine use disorder (NCT03242928), the evidence base for Stalicla's planned Phase 3. ↗

See the full catalyst calendar →

Compounds in development (2)

Compound	Company	Phase	Status	Mechanism
EMB-001 (metyrapone/oxazepam)	Embera NeuroTherapeutics, Inc.	Phase 2	Unknown	CYP11B1 Inhibitor
Mavoglurant	Stalicla SA	Phase 2	Active	mGlu5 NAM

Trials recruiting now (10)

10 drug-interventional cocaine use disorder trials recruiting now, of 98 registered interventional trials. Browse all on ClinicalTrials.gov →

Phase 4Efficacy of Clonidine in Reducing Craving in Inpatients With Cocaine and Crack Use Disorder
clonidine, clonazepam 0,25 mg
University of Sao Paulo General Hospitaln=36Brazil · 1 siteStarted Jan 2026NCT07313371
Phase 2Efficacy and Safety of Sustained-release Dexamphetamine in Patients With Moderate to Severe Cocaine Use Disorder
Sustained-release Dexamphetamine, Placebo
Parnassia Addiction Research Centren=204Netherlands · 1 siteStarted Apr 2026NCT05529927
Phase 2Repurposing Semaglutide for the Treatment of Cocaine Use Disorder
Semaglutide, Placebo
The University of Texas Health Science Center, Houstonn=75United States · 1 siteStarted Jan 2026NCT07227948
Phase 2Evaluation Of Semaglutide in Adults With Cocaine Use Disorder With and Without HIV
Semaglutide, Placebo
University of Maryland, Baltimoren=40United States · 2 sitesStarted Aug 2025NCT06691243
Phase 2Ketamine and Neurofeedback-Training: Effects on Neuroplasticity in Cocaine Addiction
Ketamine, Placebo
Dr. med. Marcus Herdenern=120Switzerland · 1 siteStarted Feb 2024NCT06125054
Phase 1/2The Impact of Cobenfy Maintenance on Cocaine's Effects
Cobenfy, Placebo
Joshua A. Lile, Ph.D.n=32United States · 1 siteStarted Aug 2026NCT07624227
Phase 0Cocaine and Pentoxifylline (BED IN 47)
Placebo, Cocaine (IV), Pentoxifylline
William Stoopsn=30United States · 1 siteStarted Nov 2025NCT07086794
Phase 0[C-11]NPA PET-amphetamine in Cocaine Use Disorders
d-amphetamine
Rajesh Narendrann=30United States · 1 siteStarted Jan 2021NCT05011760
Phase 0Imaging CRF X NOP Interactions in CUD
Hydrocortisone
Rajesh Narendrann=80United States · 1 siteStarted Dec 2020NCT05008146
UnknownThe Role of Potassium Channels in Working Memory Impairments of Chronic Cocaine Users
4-aminopyridine (4-AP), Placebo
Boris Quednown=40Switzerland · 1 siteStarted Apr 2026NCT07532460

Frequently asked

How many drugs are in development for cocaine use disorder?: 2 compounds from 2 companies are in active clinical development for cocaine use disorder.
How many clinical trials are recruiting for cocaine use disorder?: 10 drug-interventional cocaine use disorder trials are currently recruiting participants, out of 98 registered interventional trials.