How many clinical trials are recruiting for cocaine use disorder?

10 drug-interventional cocaine use disorder trials are currently recruiting participants, out of 97 registered interventional trials.

Substance Use Disorders

Cocaine use disorder drug pipeline

ICD-11 6C45
MeSH D019970
Subtype of Stimulant use disorder

Compounds in development

No compounds populated for this indication yet — see registered trials below.

Trials recruiting now (10)

10 drug-interventional cocaine use disorder trials recruiting now, of 97 registered interventional trials. Browse all on ClinicalTrials.gov →

Phase 4Efficacy of Clonidine in Reducing Craving in Inpatients With Cocaine and Crack Use Disorder
clonidine, clonazepam 0,25 mg
University of Sao Paulo General Hospitaln=36Brazil · 1 siteStarted Jan 2026NCT07313371
Phase 2Efficacy and Safety of Sustained-release Dexamphetamine in Patients With Moderate to Severe Cocaine Use Disorder
Sustained-release Dexamphetamine, Placebo
Parnassia Addiction Research Centren=204Netherlands · 1 siteStarted Apr 2026NCT05529927
Phase 2Repurposing Semaglutide for the Treatment of Cocaine Use Disorder
Semaglutide, Placebo
The University of Texas Health Science Center, Houstonn=75United States · 1 siteStarted Jan 2026NCT07227948
Phase 2Evaluation Of Semaglutide in Adults With Cocaine Use Disorder With and Without HIV
Semaglutide, Placebo
University of Maryland, Baltimoren=40United States · 2 sitesStarted Aug 2025NCT06691243
Phase 2Ketamine and Neurofeedback-Training: Effects on Neuroplasticity in Cocaine Addiction
Ketamine, Placebo
Dr. med. Marcus Herdenern=120Switzerland · 1 siteStarted Feb 2024NCT06125054
Phase 1/2The Impact of Cobenfy Maintenance on Cocaine's Effects
Cobenfy, Placebo
Joshua A. Lile, Ph.D.n=32United States · 1 siteStarted Aug 2026NCT07624227
Phase 0Cocaine and Pentoxifylline (BED IN 47)
Placebo, Cocaine (IV), Pentoxifylline
William Stoopsn=30United States · 1 siteStarted Nov 2025NCT07086794
Phase 0[C-11]NPA PET-amphetamine in Cocaine Use Disorders
d-amphetamine
Rajesh Narendrann=30United States · 1 siteStarted Jan 2021NCT05011760
Phase 0Imaging CRF X NOP Interactions in CUD
Hydrocortisone
Rajesh Narendrann=80United States · 1 siteStarted Dec 2020NCT05008146
UnknownThe Role of Potassium Channels in Working Memory Impairments of Chronic Cocaine Users
4-aminopyridine (4-AP), Placebo
Boris Quednown=40Switzerland · 1 siteStarted Apr 2026NCT07532460

Frequently asked

How many clinical trials are recruiting for cocaine use disorder?: 10 drug-interventional cocaine use disorder trials are currently recruiting participants, out of 97 registered interventional trials.