Which tourette syndrome drugs are in Phase 3?

Phase 3 (or later) programs for tourette syndrome include Ecopipam.

How many clinical trials are recruiting for tourette syndrome?

4 drug-interventional tourette syndrome trials are currently recruiting participants, out of 78 registered interventional trials.

2 compounds from 2 companies are in active clinical development for tourette syndrome, including 1 at Phase 3 or beyond.

2Compounds

2Companies

1Phase 3+

5Trials recruiting

Mechanisms: Small molecule (1) · Neuroactive Steroid (1)

Pipeline data compiled July 2026 · every fact sourced.

2026-06-18ReportedEcopipamRegulatory
Teva submitted the U.S. NDA for ecopipam in pediatric Tourette syndrome (guided for 2H 2026; submitted 2026-06-18). ↗
2026-05-26ReportedEcopipamTopline datametNCT05615220
D1AMOND Phase 3 met primary and secondary endpoints: ecopipam delayed time to relapse vs placebo in pediatric (HR=0.5, p=0.0084) and combined (HR=0.5, p=0.0050) Tourette populations; published in JAMA Neurology. ↗
2023-04-01ReportedSepranoloneTopline datamixedNCT05434546
Sepranolone Phase 2a in Tourette syndrome: 28% YGTSS tic reduction vs 12.6% control (p=0.051); all secondary endpoints (PUTS, GTS-QOL, impairment) favored sepranolone; favorable safety. ↗

Compound	Company	Phase	Status	Mechanism
EcopipamOrphanFast Track	Teva Pharmaceutical Industries Ltd.	Filed (NDA)	Active	D1 receptor Antagonist
Sepranolone	Relmada Therapeutics, Inc.	Phase 2	Completed	GABA-A receptor Antagonist

4 drug-interventional tourette syndrome trials recruiting now, of 78 registered interventional trials. Browse all on ClinicalTrials.gov →

Phase 2SCI-110 in the Treatment of Tourette Syndrome
SCI-110
Neurothera Labs Inc.n=164Germany, Israel +1 · 3 sitesStarted Jun 2026NCT05126888
Phase 2Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders
Sertraline
Holland Bloorview Kids Rehabilitation Hospitaln=130Canada · 8 sitesStarted Sep 2024NCT06081348
Phase 1Washed Microbiota Transplantation for Tourette's Syndrome
Washed Microbiota Transplantation
The Second Hospital of Nanjing Medical Universityn=30China · 2 sitesStarted Apr 2024NCT03764748
UnknownStudy on the Mechanism of Pei Tu Ning Feng Tang in Alleviating Tourette Syndrome Via Functional Near-Infrared Spectroscopy (fNIRS) and the DA-MAPK-BDNF Pathway
Tourette Syndrome (TS) children were administered Pei Tu Ning Feng Tang treatment.
Dongdong Qinn=60Started Apr 2026NCT07417371

How many drugs are in development for tourette syndrome?: 2 compounds from 2 companies are in active clinical development for tourette syndrome, including 1 at Phase 3 or beyond.
Which tourette syndrome drugs are in Phase 3?: Phase 3 (or later) programs for tourette syndrome include Ecopipam.
How many clinical trials are recruiting for tourette syndrome?: 4 drug-interventional tourette syndrome trials are currently recruiting participants, out of 78 registered interventional trials.