Which neuropathic pain drugs are in Phase 3?

Phase 3 (or later) programs for neuropathic pain include AP707.

How many clinical trials are recruiting for neuropathic pain?

73 drug-interventional neuropathic pain trials are currently recruiting participants, out of 629 registered interventional trials.

Neurological Disorders

Neuropathic pain drug pipeline

ICD-11 MG30.5
MeSH D009437

2 compounds from 2 companies are in active clinical development for neuropathic pain, including 1 at Phase 3 or beyond.

2Compounds

2Companies

1Phase 3+

79Trials recruiting

Phase 31

AP707Apurano Pharmaceuticals GmbHCB1 Partial agonist

Discontinued1

VixotrigineBiogenNav1.7 Inhibitor

Mechanisms: Natural product (1) · Small molecule (1)

Pipeline data compiled September 2026 · every fact sourced.

Upcoming readouts & recent results

2021-09-16ReportedVixotrigineTopline datamixedNCT03339336
Phase 2 CONVEY topline in painful small fiber neuropathy: vixotrigine 200 mg BID met the primary endpoint (change from baseline in average daily pain at Week 12 of the double-blind period, p=0.050 vs placebo); 350 mg BID did not (p=0.70). ↗

See the full catalyst calendar →

Compounds in development (2)

Compound	Company	Phase	Status	Mechanism
AP707	Apurano Pharmaceuticals GmbH	Phase 3	Unknown	CB1 Partial agonist
Vixotrigine	Biogen	Discontinued	Discontinued	Nav1.7 Inhibitor

Trials recruiting now (73)

73 drug-interventional neuropathic pain trials recruiting now, of 629 registered interventional trials. Browse all on ClinicalTrials.gov →

Phase 4Evaluation of an ATP-Containing Parenteral Vitamin B Complex in Patients With Symptomatic Diabetic Polyneuropathy
adenosine triphosphate, Vitamin B Complex
Egyptian International Pharmaceutical Industries Con=200Started Jan 2026NCT07296354
Phase 4Efficacy and Safety of Mirogabalin in Diabetic Peripheral Neuropathic Pain
Mirogabalin, Pregabalin
Bangladesh Medical Universityn=78Bangladesh · 1 siteStarted Oct 2025NCT07451431
Phase 4Ketamine for Postherpetic Neuralgia With Depression
Intravenous Ketamine Infusions, Intravenous normal saline, Oral Duloxetine 60mg
Huazhong University of Science and Technologyn=50Started Jun 2025NCT06968624
Phase 4Capsaicin in Digital Osteoarthritis Versus Control
Capsaicin 179 Mg Cutaneous Patch, Capsaicine low dose 0.04 %
University Hospital, Clermont-Ferrandn=120France · 4 sitesStarted Mar 2025NCT06444919
Phase 4High-Voltage Long-Duration Pulsed Radiofrequency Combined With Liposomal Bupivacaine Subcutaneous Block for Herpes Zoster-Associated Neuralgia
High-Voltage Long-Duration Pulsed Radiofrequency plus Liposomal Bupivacaine group
Shirong Tann=46China · 1 siteStarted Dec 2024NCT06959147
Phase 4The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD
Ketamine, Magnesium sulfate, Ketamine + Magnesium sulfate
Margaux M. Salas, PhDn=30United States · 1 siteStarted Oct 2024NCT06414356
Phase 4Effect of Pregabalin on Shoulder Pain in Patients With Central Sensitization After Arthroscopic Rotator Cuff Repair
Pregabalin
The Catholic University of Korean=76Started Sep 2024NCT06367998
Phase 4Transvaginal Versus Fluoroscopy-guided Trans Gluteal Pudendal Nerve Block for Pudendal Neuralgia
Bupivacaine injection
University of Louisvillen=40United States · 1 siteStarted Jun 2024NCT06644261
Phase 4OnabotulinumtoxinA for Trigeminal Neuralgia
OnabotulinumtoxinA 100 UNT [Botox], Sodium Chloride 0.9% for Injection, Preservative Free
Stanford Universityn=20United States · 1 siteStarted Jun 2024NCT06216886
Phase 4Low Dose Naltrexone for Pain in Patients With HIV
Low Dose Naltrexone
Emory Universityn=60United States · 3 sitesStarted Apr 2023NCT05537935
Phase 3Gabapentin and Oxcarbazepine for Chronic Neuropathic Pain in Children and Adolescents: A Clinical Effectiveness Study
Gabapentin, Oxcarbazepine
Boston Children's Hospitaln=60United States · 1 siteStarted Jun 2026NCT02219373
Phase 3Cervical Facet Injection of Corticosteroids for the Management of Cervicobrachialgia
Dexamethasone
Assistance Publique - Hôpitaux de Parisn=70France · 1 siteStarted Jan 2026NCT07084285

Showing the 12 most advanced of 73 recruiting drug trials · see all on ClinicalTrials.gov →

Frequently asked

How many drugs are in development for neuropathic pain?: 2 compounds from 2 companies are in active clinical development for neuropathic pain, including 1 at Phase 3 or beyond.
Which neuropathic pain drugs are in Phase 3?: Phase 3 (or later) programs for neuropathic pain include AP707.
How many clinical trials are recruiting for neuropathic pain?: 73 drug-interventional neuropathic pain trials are currently recruiting participants, out of 629 registered interventional trials.