How many clinical trials are recruiting for frontotemporal dementia?

7 drug-interventional frontotemporal dementia trials are currently recruiting participants, out of 63 registered interventional trials.

Frontotemporal dementia drug pipeline

1 compound from 1 company is in active clinical development for frontotemporal dementia.

1Compound

1Company

0Phase 3+

17Trials recruiting

Discontinued1

Mechanisms: Biologic (1)

Pipeline data compiled September 2026 · every fact sourced.

2025-10-21ReportedLatozinemabTopline datamissedNCT04374136
Phase 3 INFRONT-3 failed: latozinemab significantly raised plasma progranulin (biomarker co-primary met) but did not slow FTD-GRN clinical progression on CDR plus NACC FTLD-SB (clinical co-primary missed); open-label extension and continuation study discontinued. ↗

Compound	Company	Phase	Status	Mechanism
LatozinemabFDA Orphan Drug (Frontotemporal Dementia; June 2018)FDA Breakthrough Therapy (FTD-GRN; February 2024)	Alector Inc.	Discontinued	Discontinued	Sortilin Antagonist

7 drug-interventional frontotemporal dementia trials recruiting now, of 63 registered interventional trials. Browse all on ClinicalTrials.gov →

Phase 4Lemborexant for Insomnia in a Patient With Dementia: An N-of-1 Trial
Lemborexant 5 MG
Nova Scotia Health Authorityn=1Canada · 1 siteStarted Dec 2023NCT06093126
Phase 2Clinical Study of Neflamapimod in Patients With Primary Progressive Aphasia
Neflamapimod, Placebo
EIP Pharma Incn=20United Kingdom, United States · 7 sitesStarted Oct 2025NCT07033481
Phase 2Investigator Initiated Study for the Safety and Efficacy in Frontotemporal Dementia
NS101 IV infusion, Placebo IV Infusion
Hee-Jin Kimn=15Started Oct 2025NCT07154485
Phase 2Vortioxetine for the Treatment of Mood and Cognitive Symptoms in Frontotemporal Dementia
Vortioxetine
Johns Hopkins Universityn=50United States · 1 siteStarted Mar 2025NCT06604520
Phase 2Nabilone for Agitation in Frontotemporal Dementia
Nabilone, Placebo
Simon Ducharme, MDn=45Canada · 7 sitesStarted Mar 2023NCT05742698
Phase 1Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology
Verdiperstat
Peter Ljubenkov, MDn=64United States · 5 sitesStarted Apr 2022NCT05184569
Phase 0Propranolol in Primary Progressive Aphasia
Propranolol, Placebo
University of Missouri-Columbian=30United States · 1 siteStarted Jan 2025NCT06066710

How many drugs are in development for frontotemporal dementia?: 1 compound from 1 company is in active clinical development for frontotemporal dementia.
How many clinical trials are recruiting for frontotemporal dementia?: 7 drug-interventional frontotemporal dementia trials are currently recruiting participants, out of 63 registered interventional trials.