Anorexia nervosa drug pipeline

Upcoming readouts & recent results

• 2025-08-01ReportedPsilocybin (COMP360)Topline datamixedNCT05481736

  Phase 2 anorexia PoC (NCT05481736, n=32): encouraging improvement in eating-disorder symptoms sustained through 12 weeks on 25mg, but underpowered with heavy control-arm dropout ↗

See the full catalyst calendar →

Compounds in development (1)

Trials recruiting now (12)

12 drug-interventional anorexia nervosa trials recruiting now, of 63 registered interventional trials. Browse all on ClinicalTrials.gov →

• Phase 3Pediatric Prolonged-Release Melatonin for Sleep Disturbances in Children and Adolescents With Anorexia Nervosa (MELSom-ANOREXIA)

  Pediatric Prolonged-Released Melatonin (PedPRM), Placebo

  Assistance Publique Hopitaux De Marseillen=120France · 1 siteStarted Sep 2026NCT07576764
• Phase 2An Open Trial of a Novel Pharmacotherapy for Habit Modification in Anorexia Nervosa

  Donepezil

  New York State Psychiatric Instituten=10United States · 1 siteStarted Jun 2026NCT06518941
• Phase 2Safety, Therapeutic Potential, and Mechanisms of Two Psilocybin Doses, Administered With Psychological Support in Young Adults With Anorexia Nervosa

  Psilocybin

  Region Skanen=40Sweden · 1 siteStarted Apr 2026NCT07169747
• Phase 2Ketamine Effects on Learning In Eating Disorders

  Ketamine infusion

  Amanda Downey, MDn=20United States · 1 siteStarted Jun 2025NCT06736769
• Phase 2Study of Psilocybin for Anorexia in Young Adults

  Psilocybin

  Marissa Raymond-Flesch, MD, MPHn=40United States · 2 sitesStarted Nov 2024NCT06399263
• Phase 2Acetylcholinesterase Inhibitor in Anorexia Nervosa: Multicenter, Double-Blind, Placebo-Controlled Trial

  Donepezil 2.5 mg, Donepezil 5 mg, Placebo Comparator

  Centre Hospitalier St Annen=147Started Nov 2024NCT06687993
• Phase 2Metreleptin in Anorexia Nervosa

  Metreleptin, Sodium chloride

  Gabriella Milosn=50Switzerland · 1 siteStarted May 2024NCT06305182
• Phase 2Comparing Olanzapine and Mirtazapine in the Improvement of Unintentional Weight Loss for Patients with Advanced Stage Cancer

  Mirtazapine, Olanzapine

  Englewood Hospital and Medical Centern=170United States · 1 siteStarted Jan 2022NCT05170919
• Phase 2Transdermal Estrogen in Women With Anorexia Nervosa

  Transdermal estrogen, Placebos

  Pouneh K. Fazeli, MDn=66United States · 1 siteStarted Aug 2020NCT03875378
• Phase 0Naltrexone Neuroimaging in Teens With Eating Disorders

  Naltrexone, Placebo

  Children's Mercy Hospital Kansas Cityn=60United States · 1 siteStarted Sep 2022NCT05509257
• UnknownFecal Microbiota Transplant for Anorexia Nervosa

  Fecal Microbiota Transplant, Placebo

  Hamilton Health Sciences Corporationn=20Started Jun 2026NCT06593366
• UnknownA Study on the Effects of Combined FMT on Gut Microbiota and Eating Disorder Symptoms in AN

  Fecal Microbiota Transplantation, Placebo

  Shanghai Mental Health Centern=30Started Sep 2025NCT06744751