Suicidal ideation drug pipeline

Compounds in development

No compounds populated for this indication yet — see registered trials below.

Trials recruiting now (14)

14 drug-interventional suicidal ideation trials recruiting now, of 81 registered interventional trials. Browse all on ClinicalTrials.gov →

• Phase 3Evaluation of the Efficacy and Safety of Subcutaneous Ketamine in the Treatment of Depressive Episode With Suicidal Ideation and/or Behavior in Adolescents

  ketamine, Midazolam

  Federal University of São Paulon=60Started May 2025NCT06957704
• Phase 3Add-on Buprenorphine at Analgesic Doses for the Treatment of Severe Suicidal Ideas During a Major Depressive Episode

  Buprenorphine, Placebo

  Centre Hospitalier Universitaire de Nīmesn=180France · 9 sitesStarted Oct 2021NCT03646058
• Phase 2/3Understanding and Treating Suicidal Ideation With Ketamine

  ketamine hydrochloride

  The Royal's Institute of Mental Health Researchn=36Canada · 1 siteStarted Apr 2025NCT06891300
• Phase 2/3Ketamine & Crisis Response Plan for Suicidal Ideation in the ED

  Ketamine Hydrochloride

  The University of Texas Health Science Center at San Antonion=24United States · 1 siteStarted Jan 2023NCT05696691
• Phase 2Inhaled DMT for Major Depressive Disorder

  N,N-Dimethyltryptamine (15 mg + 60 mg), N,N-Dimethyltryptamine (1 mg + 4 mg)

  Universidade Federal do Rio Grande do Norten=140Brazil · 5 sitesStarted Aug 2026NCT07562191
• Phase 2Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)

  Ketamine Hydrochloride, Midazolam Hydrochloride

  Joshua Rosenblatn=120Started Jun 2026NCT07569198
• Phase 2Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality

  Psilocybin

  The University of Texas Health Science Center, Houstonn=10United States · 1 siteStarted Jul 2025NCT06706232
• Phase 2Nitrous Oxide in the Treatment of Acute Suicidal Ideation

  50% N2O plus 50% O2, Oxygen (O2)

  University of Zurichn=85Switzerland · 1 siteStarted Jan 2025NCT06636357
• Phase 2iTBS+D-Cycloserine for Youth Suicide

  D-Cycloserine, Placebo oral tablet

  University of Calgaryn=54Canada · 1 siteStarted Mar 2024NCT06121284
• Phase 2i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical Trial

  Ketamine hydrochloride, Midazolam Hydrochloride

  University Health Network, Toronton=110Canada · 1 siteStarted Jan 2024NCT06480500
• Phase 2The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects

  Perampanel 6 MG, Ketamine, Placebo

  Yale Universityn=30United States · 1 siteStarted Apr 2023NCT05786066
• Phase 1Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department

  Ketamine

  Lindsay Maguire, MDn=50United States · 2 sitesStarted May 2024NCT06085937

Showing the 12 most advanced of 14 recruiting drug trials · see all on ClinicalTrials.gov →