Drug target
GABA-A receptor
Gamma-aminobutyric acid type A receptor (benzodiazepine site)
4 compounds in the CNS pipeline act on GABA-A receptor.
Compounds targeting GABA-A receptor
| Compound | Action | Affinity | Lead program | Developer |
|---|---|---|---|---|
| LPCN 1154 (oral brexanolone)primaryNeuroactive Steroid | PAM | — | Phase 3Postpartum depression | Lipocine Inc. |
| GlyphAllo (SPT-300)primaryNeuroactive Steroid | PAM | — | Phase 2Major depressive disorder | Seaport Therapeutics, Inc. |
| SepranoloneprimaryNeuroactive Steroid | Antagonist | — | Phase 2Tourette syndrome | Relmada Therapeutics, Inc. |
| EMB-001 (metyrapone/oxazepam)Small molecule | PAM | — | Phase 2Cocaine use disorder | Embera NeuroTherapeutics, Inc. |