Drug target · GRIN1

NMDA receptor

N-methyl-D-aspartate (NMDA) glutamate receptor

5 compounds in the CNS pipeline act on NMDA receptor.

Compounds targeting NMDA receptor

CompoundActionAffinityLead programDeveloper
AXS-05 (dextromethorphan-bupropion)primarySmall moleculeAntagonist—Phase 2Tobacco use disorderAxsome Therapeutics, Inc.
Blixeprodil (GM-1020)primarySmall moleculeAntagonistKi 3.25 µMPhase 2Major depressive disorderGilgamesh Pharmaceuticals, Inc.
AVP-786 (deudextromethorphan-quinidine)primarySmall moleculeAntagonist—DiscontinuedAgitation in Alzheimer's diseaseAvanir Pharmaceuticals
DalzanemdorprimarySmall moleculePAM—DiscontinuedHuntington's diseaseSage Therapeutics, Inc.
Esmethadone (REL-1017)Small moleculeAntagonist—DiscontinuedMajor depressive disorderRelmada Therapeutics, Inc.