Drug target · GRIN1

NMDA receptor

Glutamate ionotropic receptor NMDA type

3 compounds in the CNS pipeline act on NMDA receptor.

Compounds targeting NMDA receptor

CompoundActionAffinityLead programDeveloper
AXS-05 (dextromethorphan-bupropion)primarySmall moleculeAntagonist—ApprovedAgitation in Alzheimer's diseaseAxsome Therapeutics, Inc.
Blixeprodil (GM-1020)primarySmall moleculeAntagonistKi 3.25 µMPhase 2Major depressive disorderGilgamesh Pharmaceuticals, Inc.
Esmethadone (REL-1017)Small moleculeAntagonist—DiscontinuedMajor depressive disorderRelmada Therapeutics, Inc.