Drug target
Presynaptic glutamate release (voltage-gated Na+ channels)
Voltage-gated sodium channels / presynaptic glutamate release machinery
2 compounds in the CNS pipeline act on Presynaptic glutamate release (voltage-gated Na+ channels).
Compounds targeting Presynaptic glutamate release (voltage-gated Na+ channels)
| Compound | Action | Affinity | Lead program | Developer |
|---|---|---|---|---|
| EvenamideprimarySmall molecule | Inhibitor | — | Phase 3Schizophrenia | Newron Pharmaceuticals S.p.A. |
| Troriluzole (BHV-4157)Small molecule | Inhibitor | — | DiscontinuedObsessive-compulsive disorder | Biohaven Ltd. |