Drug target · TMEM97

σ2 receptor (TMEM97)

Sigma-2 receptor / transmembrane protein 97

2 compounds in the CNS pipeline act on σ2 receptor (TMEM97).

Compounds targeting σ2 receptor (TMEM97)

CompoundActionAffinityLead programDeveloper
ZervimesineprimarySmall moleculeAntagonist—Phase 2Alzheimer's diseaseCognition Therapeutics, Inc.
Roluperidone (MIN-101)Small moleculeAntagonistKi 7.53 nMPhase 3SchizophreniaMinerva Neurosciences, Inc.