Drug target · TAAR1

TAAR1

Trace amine-associated receptor 1

4 compounds in the CNS pipeline act on TAAR1.

Compounds targeting TAAR1

CompoundActionAffinityLead programDeveloper
Ulotaront (SEP-363856)primarySmall moleculeAgonistEC50 38 nMPhase 2/3Generalized anxiety disorderOtsuka Pharmaceutical Co., Ltd.
RalmitarontprimarySmall moleculePartial agonistpEC50 7.75DiscontinuedSchizophreniaF. Hoffmann-La Roche Ltd
Psilocybin (COMP360)PsychedelicAgonistKi 1.4 nMPhase 3Treatment-resistant depressionCOMPASS Pathways plc
Solriamfetol (Sunosi)Small moleculeAgonist—Phase 3Binge eating disorderAxsome Therapeutics, Inc.