Drug target · SLC6A2
Norepinephrine transporter (NET)
Solute carrier family 6 member 2
3 compounds in the CNS pipeline act on Norepinephrine transporter (NET).
Compounds targeting Norepinephrine transporter (NET)
| Compound | Action | Affinity | Lead program | Developer |
|---|---|---|---|---|
| Ammoxetine (S-071031B)Small molecule | Inhibitor | — | Phase 3Major depressive disorder | CSPC ZhongQi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. |
| AXS-05 (dextromethorphan-bupropion)Small molecule | Reuptake inhibitor | — | Phase 2Tobacco use disorder | Axsome Therapeutics, Inc. |
| AVP-786 (deudextromethorphan-quinidine)Small molecule | Reuptake inhibitor | — | DiscontinuedAgitation in Alzheimer's disease | Avanir Pharmaceuticals |