Drug target · SIGMAR1
Sigma-1 receptor
Sigma non-opioid intracellular receptor 1
1 compound in the CNS pipeline acts on Sigma-1 receptor.
Compounds targeting Sigma-1 receptor
| Compound | Action | Affinity | Lead program | Developer |
|---|---|---|---|---|
| AXS-05 (dextromethorphan-bupropion)Small molecule | Agonist | — | ApprovedAgitation in Alzheimer's disease | Axsome Therapeutics, Inc. |