Drug target · SIGMAR1

Sigma-1 receptor

Sigma non-opioid intracellular receptor 1

2 compounds in the CNS pipeline act on Sigma-1 receptor.

Compounds targeting Sigma-1 receptor

CompoundActionAffinityLead programDeveloper
AXS-05 (dextromethorphan-bupropion)Small moleculeAgonist—Phase 2Tobacco use disorderAxsome Therapeutics, Inc.
AVP-786 (deudextromethorphan-quinidine)Small moleculeAgonist—DiscontinuedAgitation in Alzheimer's diseaseAvanir Pharmaceuticals