Drug target · HCRTR2

OX2R

Orexin receptor type 2 (hypocretin receptor 2)

3 compounds in the CNS pipeline act on OX2R.

Compounds targeting OX2R

CompoundActionAffinityLead programDeveloper
OveporextonprimarySmall moleculeAgonistFiled (NDA)NarcolepsyTakeda Pharmaceutical Company Limited
AlixorextonprimarySmall moleculeAgonistPhase 3NarcolepsyAlkermes plc
Seltorexant (JNJ-42847922)primarySmall moleculeAntagonistpKi 8Phase 3Major depressive disorderJohnson & Johnson