Drug target · OPRM1
MOR
Mu opioid receptor
2 compounds in the CNS pipeline act on MOR.
Compounds targeting MOR
| Compound | Action | Affinity | Lead program | Developer |
|---|---|---|---|---|
| IcalcaprantSmall molecule | Antagonist | — | Phase 2Major depressive disorder | Cerevel Therapeutics |
| Navacaprant (NMRA-140)Small molecule | Antagonist | IC50 110 nM | DiscontinuedMajor depressive disorder | Neumora Therapeutics, Inc. |