Drug target · OPRM1

MOR

Mu opioid receptor

2 compounds in the CNS pipeline act on MOR.

Compounds targeting MOR

CompoundActionAffinityLead programDeveloper
IcalcaprantSmall moleculeAntagonistPhase 2Major depressive disorderCerevel Therapeutics Holdings, Inc.
Navacaprant (NMRA-140)Small moleculeAntagonistIC50 110 nMDiscontinuedMajor depressive disorderNeumora Therapeutics, Inc.