Drug target · OPRK1

KOR

Kappa opioid receptor

3 compounds in the CNS pipeline act on KOR.

Compounds targeting KOR

CompoundActionAffinityLead programDeveloper
IcalcaprantprimarySmall moleculeAntagonist—Phase 2Major depressive disorderCerevel Therapeutics Holdings, Inc.
AticaprantprimarySmall moleculeAntagonistKi 0.81 nMDiscontinuedMajor depressive disorderJohnson & Johnson
Navacaprant (NMRA-140)primarySmall moleculeAntagonistIC50 0.8 nMDiscontinuedMajor depressive disorderNeumora Therapeutics, Inc.