Drug target · MAPT

Tau (pT217)

Microtubule-associated protein tau, phosphorylated at threonine-217 (proline-rich domain)

3 compounds in the CNS pipeline act on Tau (pT217).

Compounds targeting Tau (pT217)

CompoundActionAffinityLead programDeveloper
JNJ-2056 (ACI-35.030)primaryBiologicAgonist—Phase 2Alzheimer's diseaseJohnson & Johnson
MK-2214primaryBiologicInhibitor—Phase 2Alzheimer's diseaseMerck & Co., Inc.
PosdinemabprimaryBiologicInhibitor—DiscontinuedAlzheimer's diseaseJohnson & Johnson