Drug target · HCRTR2
OX2R
Orexin receptor type 2 (OX2)
3 compounds in the CNS pipeline act on OX2R.
Compounds targeting OX2R
| Compound | Action | Affinity | Lead program | Developer |
|---|---|---|---|---|
| Fazamorexant (YZJ-1139)primarySmall molecule | Antagonist | IC50 41 nM | ApprovedInsomnia | Yangtze River Pharmaceutical Group |
| Vornorexant (TS-142)primarySmall molecule | Antagonist | IC50 1.76 nM | ApprovedInsomnia | Taisho Pharmaceutical Co., Ltd. |
| TAK-360primarySmall molecule | Agonist | — | Phase 2Narcolepsy | Takeda Pharmaceutical Company Limited |