Drug target · HCRTR2
OX2 receptor
Orexin receptor type 2 (hypocretin receptor 2)
2 compounds in the CNS pipeline act on OX2 receptor.
Compounds targeting OX2 receptor
| Compound | Action | Affinity | Lead program | Developer |
|---|---|---|---|---|
| Vornorexant (TS-142)primarySmall molecule | Antagonist | IC50 1.76 nM | ApprovedInsomnia | Taisho Pharmaceutical Co., Ltd. |
| TAK-360primarySmall molecule | Agonist | — | Phase 2Narcolepsy | Takeda Pharmaceutical Company Limited |