Drug target · HCRTR1
OX1R
Orexin receptor type 1 (OX1)
2 compounds in the CNS pipeline act on OX1R.
Compounds targeting OX1R
| Compound | Action | Affinity | Lead program | Developer |
|---|---|---|---|---|
| Fazamorexant (YZJ-1139)Small molecule | Antagonist | IC50 32 nM | ApprovedInsomnia | Yangtze River Pharmaceutical Group |
| Vornorexant (TS-142)Small molecule | Antagonist | IC50 1.61 nM | ApprovedInsomnia | Taisho Pharmaceutical Co., Ltd. |