Drug target · GRM3
mGlu3
Metabotropic glutamate receptor 3
2 compounds in the CNS pipeline act on mGlu3.
Compounds targeting mGlu3
| Compound | Action | Affinity | Lead program | Developer |
|---|---|---|---|---|
| Pomaglumetad methionilSmall molecule | Agonist | Ki 92 nM | DiscontinuedSchizophrenia | Eli Lilly and Company |
| TS-161Small molecule | Antagonist | Ki 2.83 nM | DiscontinuedTreatment-resistant depression | Taisho Pharmaceutical Co., Ltd. |