Drug target · GRM2

mGlu2

Metabotropic glutamate receptor 2

3 compounds in the CNS pipeline act on mGlu2.

Compounds targeting mGlu2

CompoundActionAffinityLead programDeveloper
MK-1942primarySmall moleculeNAM—DiscontinuedTreatment-resistant depressionMerck & Co., Inc.
Pomaglumetad methionilprimarySmall moleculeAgonistKi 149 nMDiscontinuedSchizophreniaEli Lilly and Company
TS-161primarySmall moleculeAntagonistKi 4.27 nMDiscontinuedTreatment-resistant depressionTaisho Pharmaceutical Co., Ltd.