Drug target · DRD4

D4

Dopamine D4 receptor

2 compounds in the CNS pipeline act on D4.

Compounds targeting D4

Compound	Action	Affinity	Lead program	Developer
Brilaroxazine (RP5063)Small molecule	Partial agonist	Ki 6 nM	Phase 3Schizophrenia	Reviva Pharmaceuticals Holdings, Inc.
ENX-104Small molecule	Antagonist	—	Phase 1Major depressive disorder	Engrail Therapeutics, Inc.