Drug target · DRD3

D3

Dopamine D3 receptor

4 compounds in the CNS pipeline act on D3.

Compounds targeting D3

CompoundActionAffinityLead programDeveloper
ALTO-207primarySmall moleculeAgonistpKi 8.5Phase 2Treatment-resistant depressionAlto Neuroscience, Inc.
Brilaroxazine (RP5063)Small moleculePartial agonistKi 3.7 nMPhase 3SchizophreniaReviva Pharmaceuticals Holdings, Inc.
LB-102 (N-methylamisulpride)Small moleculeAntagonistKi 0.8 nMPhase 3SchizophreniaLB Pharmaceuticals Inc.
ENX-104Small moleculeAntagonist—Phase 1Major depressive disorderEngrail Therapeutics, Inc.