Drug target · CHRNA7

alpha7 nAChR

Nicotinic acetylcholine receptor alpha7 subunit

3 compounds in the CNS pipeline act on alpha7 nAChR.

Compounds targeting alpha7 nAChR

CompoundActionAffinityLead programDeveloper
VQW-765primarySmall moleculePartial agonistEC50 7.5 uMPhase 3Social anxiety disorderVanda Pharmaceuticals Inc.
BNC210 (soclenicant)primarySmall moleculeNAM—Phase 2Post-traumatic stress disorderNeuphoria Therapeutics, Inc.
MK-1167primarySmall moleculePAMEC50 1.3 uMPhase 2Alzheimer's diseaseMerck & Co., Inc.