Drug target · CHRM4

M4

Muscarinic acetylcholine receptor M4

6 compounds in the CNS pipeline act on M4.

Compounds targeting M4

CompoundActionAffinityLead programDeveloper
Xanomeline/trospium chloride (Cobenfy)primarySmall moleculeAgonist—ApprovedSchizophreniaKaruna Therapeutics
Direclidine (NBI-1117568)primarySmall moleculeAgonist—Phase 3SchizophreniaNeurocrine Biosciences, Inc.
Emraclidine (CVL-231)primarySmall moleculePAM—Phase 2SchizophreniaCerevel Therapeutics
NBI-1117570primarySmall moleculeAgonist—Phase 2SchizophreniaNeurocrine Biosciences, Inc.
NS-136primarySmall moleculePAM—Phase 2SchizophreniaNeuShen Therapeutics
ML-007C-MASmall moleculeAgonistEC50 830 nMPhase 2SchizophreniaMapLight Therapeutics, Inc.