Drug target · CHRM1
M1
Muscarinic acetylcholine receptor M1
5 compounds in the CNS pipeline act on M1.
Compounds targeting M1
| Compound | Action | Affinity | Lead program | Developer |
|---|---|---|---|---|
| ML-007C-MAprimarySmall molecule | Agonist | EC50 120 nM | Phase 2Schizophrenia | MapLight Therapeutics, Inc. |
| TNX-102 SL (cyclobenzaprine HCl sublingual)Small molecule | Antagonist | Ki 7.9 nM | ApprovedFibromyalgia | Tonix Pharmaceuticals Holding Corp. |
| Xanomeline/trospium chloride (Cobenfy)Small molecule | Agonist | — | ApprovedSchizophrenia | Karuna Therapeutics |
| Olanzapine extended-release injectable suspension (TEV-'749)Small molecule | Antagonist | — | Filed (NDA)Schizophrenia | Teva Pharmaceutical Industries Ltd. |
| NBI-1117570Small molecule | Agonist | — | Phase 2Schizophrenia | Neurocrine Biosciences, Inc. |