Drug target · AVPR1A
V1A receptor
Arginine vasopressin receptor 1A
4 compounds in the CNS pipeline act on V1A receptor.
Compounds targeting V1A receptor
| Compound | Action | Affinity | Lead program | Developer |
|---|---|---|---|---|
| NTX-1472primarySmall molecule | Antagonist | Ki 0.5 nM | Phase 2Social anxiety disorder | F. Hoffmann-La Roche Ltd |
| NMRA-511primarySmall molecule | Antagonist | — | Phase 1Agitation in Alzheimer's disease | Neumora Therapeutics, Inc. |
| BalovaptanprimarySmall molecule | Antagonist | Ki 0.7 nM | DiscontinuedAutism spectrum disorder | F. Hoffmann-La Roche Ltd |
| Nelivaptan (BH-200)Small molecule | Antagonist | pKi 7 | Phase 2Major depressive disorder | Sanofi |