Drug target

AMPA receptor

Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (ionotropic glutamate receptor, AMPA subtype)

2 compounds in the CNS pipeline act on AMPA receptor.

Compounds targeting AMPA receptor

CompoundActionAffinityLead programDeveloper
DT-101primarySmall moleculePAM—Phase 2Major depressive disorderDraig Therapeutics Ltd
RAP-219Small moleculeNAM—Phase 3EpilepsyRapport Therapeutics, Inc.