2026 ECNP Congress

PS03-3067

Association between lonliness, social isolation, and suicidality

Ji Hyun An — Samsung Medical Center, Department of Psychiatry, Seoul, Korea- Rep

Objectives: The study highlights that social isolation and loneliness are profound social determinants of health, significantly linked to suicidality within the general population. While often used interchangeably, this research distinguishes between the subjective experience of loneliness and objective measures like social support and social network size. Methods: Utilizing a massive nationwide, population-based cohort of 5,511 Koreans aged 18 to 79, the researchers employed the Loneliness and Social Isolation Scale (LSIS) and the Korean version of the WHO-Composite International Diagnostic Interview (K-CIDI) to measure these variables alongside lifetime suicidal ideation and suicide attempts. The methodology involved rigorous face-to-face interviews to account for sociodemographic factors and psychiatric comorbidities, using multiple logistic regression to isolate the specific impact of social disconnection. Results: The results provide a compelling quantitative map of how social deficits translate into suicidal risk. On a broad scale, higher total scores for combined social isolation and loneliness were associated with increased odds of suicidal ideation (AOR 1.19, 95% CI 1.15-1.23) and suicdie attempts (AOR 1.22, 95% CI 1.15-1.29). However, the subscale analysis revealed more nuanced drivers. Specifically, a higher score in loneliness was the most potent predictor, showing a staggering association with suicidal ideation (AOR 1.51, 95% CI 1.43-1.60). Lower social support (AOR 1.15, 95% CI 1.09-1.22) and smaller social networks (AOR 1.18, 95% CI 1.09-1.27) were also significantly linked to suicidal ideation. When examining actual suicide attempts, the distinctions became even sharper: only loneliness (AOR 1.63, 95% CI 1.44-1.84) and a diminished social network (AOR 1.40, 95% 1.18-1.66) remained statistically significant associations. Interestingly, social support alone did not show a direct, independent link to suicide attempts in the same way. The study also found that as the sum of any two subscales increased—such as experiencing both loneliness and a lack of social support—the odds of both suicidal ideation and suicidal attempts rose accordingly. Loneliness emerged as the undisputed strongest factor in this triad. This was most evident in its relationship with repeat behavior; the effect of loneliness on suicidal attempts was significantly higher in individuals with multiple attempts (AOR 1.66, 95% 1.47-1.88) compared to those with a single attempt. This suggests a deepening cycle where subjective isolation fuels persistent suicidality. Conclusion: Ultimately, the study concludes that while poor social support and limited networks are dangerous, the subjective feeling of loneliness plays the most critical role in driving a person from ideation to action. Even after adjusting for common psychiatric disorders, these social factors remain primary drivers of suicidality, indicating that mental health interventions must look beyond clinical symptoms to address the fundamental human need for perceived connection and belonging. This evidence underscores the necessity of public health strategies that prioritize the reduction of loneliness as a primary means of suicide prevention in the general population.

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